A friend of mine told me about this puzzle game available through steam called spacechem! I found it quite clever and love it so far... Here's a youtube video to have a look at it: http://www.youtube.com/watch?v=RjYOYtd298o It's available through steam for those of you that can afford it, for those that can't you can download it here: http://www.rlslog.net/spacechem-v1007-incl-serial-theta-osx-linux/
The later levels of that look like they'd melt my mind. Very interesting puzzle game. Think I'm going to gift this to a friend of mine who keeps saying puzzle games are to easy. He'll shut it with this. =D